Pure Crocin For Pharmaceutical Usages

Crocin, a natural carotenoid pigment isolated from the saffron plant (Crocus sativus), has attracted considerable attention in recent years due to its unique pharmacological properties. Achieving a 99.93% purity level in crocin is of special significance, as pure saffron extract has a wide range of essential pharmaceutical applications, which we will briefly describe here.

 

Benefits of Crocin:

Pure crocin, with its high-purity crocin, is essential in pharmaceuticals due to its numerous health benefits. These benefits include:

  1. Antioxidant Effects: Crocin helps in neutralizing harmful free radicals in the body, reducing oxidative stress, and preventing cell damage.

  2. Anti-inflammatory Properties: It significantly reduces inflammation, making it beneficial for treating conditions like arthritis and other inflammatory diseases.

  3. Neuroprotective Effects: Crocin has been shown to protect nerve cells from damage and degeneration, which is crucial for preventing and managing neurodegenerative diseases such as Alzheimer's and Parkinson's.

  4. Antidepressant and Anxiolytic Effects: Crocin has mood-enhancing properties, making it useful in the treatment of depression and anxiety disorders.

  5. Anti-cancer Properties: Research indicates that crocin may inhibit the growth of cancer cells and induce apoptosis (programmed cell death) in various cancer types.

  6. Cardioprotective Effects: Crocin contributes to heart health by reducing cholesterol levels and improving blood flow, thus preventing cardiovascular diseases.

These multifaceted health benefits make pure crocin a valuable component in modern pharmaceutical applications.

 

Structure and Characteristics of Crocin:

Crocin is a water-soluble compound responsible for the vibrant red color of saffron. Its chemical structure consists of a central dihydroxy β-cyclocitral molecule attached to a disaccharide known as gentiobiose. Understanding the intricacies of crocin's structure is vital for appreciating its purity and bioactivity.

 


 

 

Attaining 99.93% Purity:

The process of obtaining highly pure crocin is a sophisticated and precise endeavor. It involves multiple steps such as saffron extraction, solvent purification, and crystallization, all meticulously performed to

eliminate impurities and contaminants effectively. Achieving this exceptional level of purity ensures the therapeutic efficacy and safety of crocin in pharmaceutical applications.

Our company is dedicated to delivering Crocin of utmost purity, boasting an impressive 99.93% level. Our offerings are accompanied by meticulous certificates and in-depth analytical reports, guaranteeing the highest standards of quality and reliability.Pure Crocin, plays a pivotal role in pharmaceutical applications, ensuring minimal impurities and maximal therapeutic efficacy. We cater to the discerning needs of pharmaceutical professionals, providing a trusted source of this essential compound, fortified by stringent quality control measures and analytical documentation.

 

 

     Analysis of Pure Crocin

 

Technical Data

Crocin (CAS 42553-65-1)

Alternate Names: Bis(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl) 8,8'-diapo-psi, psicarotenedioate; Crocetin gentiobiose ester

CAS Number: 42553-65-1

Molecular Weight: 976.96

Molecular Formula: C44H64O24

Physical State : Solid

Storage : Store at 4° C

Melting Point : 186° C

Boiling Point : ~1169.0° C at 760 mmHg (Predicted)

Density : ~1.5 g/cm3

DEFINITION

Coloring principle of saffron (dried stigmas of flowers of Crocus sativus L). Crocins are natural drug carotenoid chemical compounds and glycosylated esters of crocetin.

 

Physicochemical analysis

Physical state

solid

Confirmed

source

Saffron stigmas

Confirmed

solubility

easily soluble in water and methanol

Confirmed

Description

Deep red color crystals. Orang solution in water

Confirmed

Spectrophotometry

Maximum absorption in water at 440 nm using

a 1 cm quartz cell.

Confirmed

 

Acceptable range

Result

Assay (HPLC)

≥90

99.93%

Loss on drying

≤ 7.5%

4%

Total ash

≤ 5%

4.4%

 

Microbial analysis

 

Acceptable range

Result

Total yeasts and molds count

≤ 100 cfu/g

0 cfu/g

Total aerobic microbial count

≤ 10000 cfu/g

0 cfu/g

Bile-tolerant bacteria gram negative

≤ 100 cfu/g

0 cfu/g

Total coliforms count

0 cfu/g

0 cfu/g

E. coli

0 cfu/g

0 cfu/g

Salmonella species

0 cfu/g

0 cfu/g

Candida albicans

0 cfu/g

0 cfu/g

Pseudomonas aeruginosa

0 cfu/g

0 cfu/g

Staphylococcus aureus

0 cfu/g

0 cfu/g